Meeting Your Match: Examining Physical Properties of Isotopes to Understand Their Effect Across Varying Disease Characteristics
Time: 8:30 am
day: Workshop A
Details:
Selecting the appropriate isotope for targeted radiotherapy involves a thorough understanding of both the properties of the isotopes and the specific characteristics of the disease being treated. This requires an integration of knowledge from nuclear physics, oncology, and immunohistopathology.
In this workshop, we will delve into considerations for isotope selection to bring optimal treatment outcomes:
- Matching isotope properties with disease properties by examining radiation type and energy from alpha, beta, and gamma emitters
- Exploring effects of isotope half-life and decay pathways, from short-lived to long-lived isotopes
- Assessing the optimal blend of biological half-life, physical half-life and targeting moiety
- Navigating criteria to be considered for isotope selection such as tumour type and location and
- microenvironmental features
- Outlining targeting mechanisms delivering the isotope to the tumour and considerations for optimal isotope selection
- Understanding immune profiles stimulated – activation and recruitment of immune cells at the tumor site after radionuclide therapy, and impact of the treatment on tumor immune resistance
