Explore the Agenda
8:00 am Check In & Coffee
Discovery & Preclinical Track
Workshop A
9:00 am Evolving Tumours & Smarter Targets: Advancing Novel TRPs with HER2 & FAP
As tumours evolve, their surface and stromal protein expressions shift, demanding precision strategies in targeted radiopharmaceutical development. To ensure sustained therapeutic efficacy, it’s essential to choose radiopharmaceutical targets that reflect these dynamic changes, especially as we move beyond traditional oncogenic markers.
- Adapt TRP Targeting to Tumour Evolution: Track changes in tumour biology and adapt radiopharmaceutical targeting strategies accordingly
- Redefining What Makes a Good TRP Target: Focus on targets with strong tumour specificity, high expression density, and internalisation potential, as these are key attributes for radioligand efficacy
- Why HER2 and FAP are Leading Candidates: HER2 enables tumour-cell directed TRP approaches, while FAP provides access to the tumour stroma, broadening reach across solid tumours
12:00 pm Lunch Break & Networking
Discovery & Preclinical Track
Workshop D
1:00 pm Designing Safer Radiopharmaceuticals – Balancing Innovation with Toxicity Management
As radiopharmaceutical therapies advance, ensuring patient safety remains paramount. This workshop offers a comprehensive overview of designing novel radiopharmaceuticals with an emphasis on minimising toxicity. We’ll explore the intricacies of molecular designrom targeting moieties to payloads and discuss strategies to mitigate associated toxicities.
- Designing safer tumour-targeted in situ RadioIMmunoStimulants (RIMS) for metastaticcastration resistant prostate cancer
- Disease Biology Insights: Understanding diseasespecific biology to inform safer drug design
- Optimising pharmacokinetics and safety to improve radiation exposure
- Toxicity Exploration: Identifying common toxicities in radiopharmaceuticals and strategies to avoid them across different modalities