Mastermind Session: Integrating Imaging-Derived Dosimetry & Target Confirmation to Optimise Therapeutic First-in-Human Study Design
- Translating diagnostic imaging biodistribution into therapeutic dose estimates and dosimetry thresholds for cycle scheduling
- Defining target expression and on-target binding criteria through pre-treatment scans to guide patient selection and reduce off-target-risk
- Planning treatment cycles and follow-up intervals based on calculated organ dose limits, expected adverse-event-kinetics, and recovery profiles