Bridging the Gap – Translating Dosimetry from Animal Models to Human Applications in TRPs

Accurate dosimetry translation from animal models to humans is crucial for the safe and effective clinical application of targeted radiopharmaceuticals. This workshop delves into the methodologies, challenges, and best practices in extrapolating dosimetric data, ensuring that preclinical findings reliably inform human therapeutic strategies.

  • Comparing various extrapolation techniques and assessing their accuracy and applicability
  • Review real-world examples where dosimetric translation informed clinical dosing, highlighting both successes and areas for improvement
  • Optimising a novel nanomedicine to maximise tumour uptake
  • Evaluating the impact of specific activity and isotope selection • Leveraging in vivo (PET) and ex vivo biodistribution
  • Dosimetry and scaling to human doses