Bala Nn Rao Attili
Director - Oncology Safety Sciences AstraZeneca
Seminars
Tuesday 11th November 2025
Elucidating Radiobiological Mechanisms of Cytotoxicity & Immune Modulation to Inform Selection of Optimal Radiopharmaceutical Targets
11:00 am
- Investigating the cellular and molecular mechanisms underlying radiopharmaceutical-induced cell death to optimise therapeutic outcomes
- Exploring how radiopharmaceuticals interact with the immune system to enhance anti-tumour immunity and reduce resistance
- Leveraging insights from radiobiology and immune modulation to identify and select optimal radiopharmaceutical targets for improved tumour control and reduced toxicity
Monday 10th November 2025
Designing Safer Radiopharmaceuticals – Balancing Innovation with Toxicity Management
1:00 pm
As radiopharmaceutical therapies advance, ensuring patient safety remains paramount. This workshop offers a comprehensive overview of designing novel radiopharmaceuticals with an emphasis on minimising toxicity. We’ll explore the intricacies of molecular designrom targeting moieties to payloads and discuss strategies to mitigate associated toxicities.
- Designing safer tumour-targeted in situ RadioIMmunoStimulants (RIMS) for metastaticcastration resistant prostate cancer
- Disease Biology Insights: Understanding diseasespecific biology to inform safer drug design
- Optimising pharmacokinetics and safety to improve radiation exposure
- Toxicity Exploration: Identifying common toxicities in radiopharmaceuticals and strategies to avoid them across different modalities
